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*Hypersensitivity
type I IgE / minutes / Ag-induce, IgE ,mast cells, vasoactive / anaphylaxis. hay. asthma. urticaria
type II Ab / hours / Ab direct / blood transfusion. autoimmune hemolytic
type III Immune-complex / hours / Ag-Ab complex deposite / SLE. RA
type IV cell / days / memory Th1, cytokines, macrophage / contact dermatitis. TB PPD test
s/s of each type?
*Systemic lupus erythematosus
BIRD MAN SOAP (4/11)
blood (anemia, XXXpenia) -> splenomega, lymphade,
immune (anti-ds-DNA, anti-sm, anti-phosph)
renal (proteinuria>500 mg/dl) (I-min.mesangial, II-mesa pro, III-focal, IV-diffuse, V-membranous, VI-advanced scle)
discoid rash
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malar rash (spares nasolabial)
arthritis
neurologic (seizures, psychosis)
--------------------------------------------------
serositis (pleuritis/pleural effusion, pericartitis)
oral / nasopharyngeal ulcers
ANA
photosensitivity
type I IgE / minutes / Ag-induce, IgE ,mast cells, vasoactive / anaphylaxis. hay. asthma. urticaria
type II Ab / hours / Ab direct / blood transfusion. autoimmune hemolytic
type III Immune-complex / hours / Ag-Ab complex deposite / SLE. RA
type IV cell / days / memory Th1, cytokines, macrophage / contact dermatitis. TB PPD test
s/s of each type?
*Systemic lupus erythematosus
BIRD MAN SOAP (4/11)
blood (anemia, XXXpenia) -> splenomega, lymphade,
immune (anti-ds-DNA, anti-sm, anti-phosph)
renal (proteinuria>500 mg/dl) (I-min.mesangial, II-mesa pro, III-focal, IV-diffuse, V-membranous, VI-advanced scle)
discoid rash
-------------------------------------------------
malar rash (spares nasolabial)
arthritis
neurologic (seizures, psychosis)
--------------------------------------------------
serositis (pleuritis/pleural effusion, pericartitis)
oral / nasopharyngeal ulcers
ANA
photosensitivity
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